The meaning of DOMINATE is rule, control. How to use dominate in a sentence. to have control over a place or person: 2. to be the largest, most important, or most…. To dominate a situation means to be the most powerful or important person or thing in it. The book is expected to dominate the best-seller lists. [VERB noun] ...countries where life is dominated by war. … Definition of dominate verb in Oxford Advanced Learner's Dictionary. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. to control, rule, or govern (someone or something) 2. to tower above (surroundings, etc); overlook dom•i•nate /ˈdɑməˌneɪt/ v. [~ + object], -nat•ed, -nat•ing. to rule over; control: She completely dominates the family. overlook: The church dominates the entire village.