Aug 1, 2025 · Adding sertraline, duloxetine, or escitalopram at standard doses to clozapine therapy may reduce the risk for schizophrenia relapse, a study finds. Clozapine is a second generation atypical antipsychotic medication used for treatment-resistant schizophrenia and to reduce the risk of suicidal behavior in patients with schizophrenia. Nov 2, 2025 · These findings support the transdiagnostic effectiveness and safety of clozapine, particularly in schizophrenia-spectrum disorders, bipolar disorder, and severe depression. We focused on the application of antidepressants in schizophrenia treatment in this review. Augmentation of antidepressants with antipsychotics is a common clinical practice to treat resistant … Aug 28, 2025 · Clozapine is an antipsychotic medicine. It works by changing the actions of chemicals in the brain. Clozapine is used to treat schizophrenia in adults after other treatments have failed. … Sep 22, 2021 · Our meta-review outlines the superior overall efficacy of clozapine compared to FGAs and most other SGAs in schizophrenia and suggests beneficial efficacy outcomes in bipolar disorder ….