Jul 17, 2024 · In studies of Otezla for plaque psoriasis, significant improvements were seen within 4 months of starting treatment. But you may start to see improvement in symptoms sooner than this. Otezla is available as a 30 mg tablet. The first five days is a start period, during which the dosage will gradually increase until the recommended dose of 30 mg (twice daily) is reached. Otezla is meant to be taken continuously to maintain improvement.See full list on psoriasis.orgIn clinical trials, there were reported cases of: 1. Gastrointestinal problems, including severe diarrhea, nausea and vomiting 2. Weight decreaseSee full list on psoriasis.orgIn clinical trials, the most common side effects were diarrhea, nausea, tension headache, headache and upper respiratory infection.See full list on psoriasis.orgOtezla can be used with other treatments such as phototherapy or topicals. It has been shown to be safe and effective when taken with methotrexate. In clinical trials, between 28 percent and 33 percent of people saw a 75 percent improvement in psoriasissymptoms after 16 weeks of treatment with Otezla, compared to about 6 percent who took placebo (an inactive treatment). Sep 30, 2025 · Otezla improves plaque psoriasissymptoms of scaling, itching, and skin redness, and reduces nail and scalp psoriasissymptoms. When used for psoriatic arthritis, Otezla improves inflammation, joint swelling, and pain. Plaque Psoriasis: Treatment with Otezla is associated with an increase in depression. During clinical trials in adult patients with moderate to severe plaque psoriasis, 1.3% (12/920) of patients reported depression compared to 0.4% (2/506) on placebo. Dec 20, 2023 · Patients treated with Otezla were more than twice as likely to report a significant improvement in whole-body itching. In clinical trials, between 28 percent and 33 percent of people saw a 75 percent improvement in psoriasissymptoms after 16 weeks of treatment with Otezla, compared to about 6 percent who took placebo (an inactive treatment).
