The meaning of MOST is greatest in quantity, extent, or degree. How to use most in a sentence. Can most be used in place of almost?: Usage Guide MOST definition: 1. the biggest number or amount of; more than anything or anyone else: 2. a great majority of; nearly all b. (as pronoun; functioning as sing or plural) 2. Click for more definitions. most (mōst), adj., [superl. of much or many with more as compar.] in the greatest quantity, amount, measure, degree, or number: to win the most votes. in the majority of instances: Most operations are … May 5, 2026 · The teams competed to see who could collect (the) most money. I spent most time in Rome because most of Venice is flooded. used to indicate the greatest amount or degree of a quality, as in "That's the exhibit's most controversial statue" or "He's the most ambitious one" Define most. most synonyms, most pronunciation, most translation, English dictionary definition of most. Superlative of many much 1. Greatest in number: won ...